An international team, including researchers from HSE University, examined an unusual SARS-CoV-2 sample obtained from an HIV-positive patient. Genetic analysis revealed multiple mutations and showed that the virus had been evolving inside the patient’s body for two years. This finding supports the theory that the virus can persist in individuals for years, gradually accumulate mutations, and eventually spill back into the population. The study's findings have been published in Frontiers in Cellular and Infection Microbiology.

Computational methods for analysing ancient and modern genomes make it possible to study the formation of genetic diversity in populations, reconstruct their history of mixing and migration, and trace the development of environmental adaptations. The HSE International Laboratory of Statistical and Computational Genomics applies mathematical methods and genetic data to address a wide range of issues across fields such as anthropology, epidemiology, and criminology. The HSE News Service spoke with the laboratory head, Vladimir Shchur, about its work.

Researchers from the AI and Digital Science Institute, HSE Faculty of Computer Science, have proposed a new approach based on advanced machine learning techniques to determine a person’s genetic origin with high accuracy. This method uses graph neural networks, which make it possible to distinguish even very closely related populations.

Researchers of the HSE International Laboratory of Statistical and Computational Genomics together with their international colleagues have proposed a new statistical method for analysing population admixture that makes it possible to determine the time and number of migration waves more accurately. The history of Colombians and Mexicans (descendants of Native Americans, Spaniards and Africans) features two episodes of admixture that occurred about 350 and 200 years ago for Mexicans and 400 and 100 years ago for Colombians. The results were published in the Plos Genetics journal.

Biologists and mathematicians from HSE University, Skoltech and the RAS Kharkevich Institute have studied the spread of COVID-19 in Russia. The main part of the study was completed in late June, but until October, the team was working with data following the reviewers’ recommendations. The paper was published on January 28, 2021 in the journal Nature Communications. MIEM students spoke about their contribution to the research.

The number of international laboratories run in cooperation with leading international scholars is set to expand at HSE University. The competition aims to support the existing and create new research teams. Applications will be accepted from July 10 to August 31, 2020.

The first research seminar of the International Laboratory of Statistical and Computational Genomics had been postponed almost a month due to COVID-19. In April, however, the event finally took place. Laboratory Head Vladimir Shchur discusses what life is like for scientists in self-isolation during the pandemic, what genomics is, and why gesturing is important when teaching online.

For ten years now, HSE has been holding an annual grant competition for researchers who wish to start new international laboratories at HSE in collaboration with leading foreign scholars and scientists. The most recent competition reached its conclusion this past November, and now some of the selected proposed labs have already begun operation. Who are the competition winners and what kind of research will they be doing?

Projects have won the competition for the creation of international laboratories at HSE University for the period from December 1, 2019 to December 31, 2022.