Research activity

The laboratory's research is at the intersection of population and evolutionary genomics, mathematical modeling, and data analysis. Methodology Scientific objectives include (but are not limited to) the following areas.

Genetic history and evolution of humans and other mammals

• The role of the Neanderthal and Denisovan components in the modern human population;

• Population and age heterogeneity of type 2 diabetes according to single cell sequencing data;

• Development of new methods for estimating the history of population size changes, time of population separation, and migration rates and directions;

• the genetic structure of the modern human population in Russia;

• Exploring the shared history of feline tigers and lions, including ancient extinct species.

Genomic epidemiology and pathogen evolution

• Assessment of the phylodynamics and phylogeography of SARS-CoV-2, influenza, hepatitis A viruses, etc.;

• mathematical modeling of migrations of migratory birds and their role in the transmission of encephalitis virus;

• studying and predicting changes in the virus fitness landscape over time;

• prediction of the multidrug resistance of Mycobacterium tuberculosis, including the determination of its genetic factors.