Cеминар с Сергеем Шмаковым

Дорогие коллеги!

Во вторник 08.04.2025 в 16:20 на семинаре выступит Сергей Шмаков, National Center for Biotechnology Information/National Library of Medicine/National Institutes of Health, USA с докладом "Computational Approaches for Uncovering Microbial Functional Diversity"

Аннотация:
Microbial organisms are essential symbionts for humans, yet they can also cause severe diseases. A large number of microbial genes remain uncharacterized, hindering our ability to fully understand their functional diversity. Unraveling this diversity is crucial for advancing human health and developing innovative biotechnological tools, such as CRISPR-Cas9, renowned for its genome editing applications. To characterize this functional diversity, we investigate the genomic language shaped by evolution. By leveraging gene context information, we developed novel computational methods for identifying functionally linked genes. Applying these methods, we discovered 14 novel CRISPR-Cas systems and identified novel regulatory mechanisms in microbial genomes. This work highlights the potential of deep contextual genomic information to surpass the limitations of current gene and system identification techniques. We anticipate these insights will lead to novel computational approaches for discovering innovative disease diagnostics, therapeutics, and advanced biotechnological applications.

Ссылка для подключения: https://us06web.zoom.us/j/85741521634?pwd=Lx1usnrmy5d2reAfOb1OC63JSHCQNw.1